PRACTICAL ORGANIC CHEMISTRY
Glycocoll.—By the action of primary and secondary amines,
corresponding amino-acids are formed. Chloracetic acid and
methylamine yield sarcosine,
CH2 + NH3CH8 = CH2 + HC1.
The amino-acids are further obtained by the reduction
(Zn and HC1) of nitro-, oximino- and cyano-acids, thus :
CHo(N().2).COOII + 3Ha= CHa(NI Ia)COOII + 2li2O,
CH3.C(NOli).COOH + 2llo = CH3.C1I(NH.,).COOII + HaO9
CN.COOH -h 2lL = CHo(NII.2).c6oH,
and by the action of NH3 on the cyanhydrin of aldehydes and
ketones, or simply of ammonium cyanide. The product is then
hydrolysed with HC1,
CH3.COH •> CII3.CII
\>H \Nl-Ia \NII,
The amino-acids are crystalline compounds usually of a sweet
taste and soluble in water. They are neutral compounds, from
which it may be assumed that an inner ammonium salt is
By the action of an acid chloride on the amino-acid, the hydro-
gen of the amino-group may be replaced by an acicl radical.
Hippuric acid has been synthesised in this way.
CH2 + C6H5COC1 = Clio + IIC1 .
The amino-acids are not acted on by a hot solution of caustic
alkali, but on fusion with caustic soda or potash, yield the
amine and CO,,,
CH,.CH - CIL.CH2.NH2